Sodium Hydroxide → HCID 21558942, compound

HRID 1578851Notes

Reaction equation

HRID 1578851 reaction equation
[O:1]([C:8]1[C:16]([S:17](=[O:30])(=[O:29])[NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[NH:25]C(=O)C)=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[NH:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>>[O:1]([C:8]1[C:16]([S:17](=[O:30])(=[O:29])[NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[NH2:25])=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[NH:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 21558944HCID 21558944, compound

Product 1

HCID 21558942HCID 21558942, compound

Procedure

The mixture of 2.5 g of 4-phenoxy-3-benzylamino-5-(2-acetamidophenylsulfamoyl)-benzoic acid and 25 ml of 2N aqueous sodium hydroxide is refluxed for four hours under nitrogen. After cooling to room temperature it is filtered, the filtrate acidified with glacial acetic acid to pH = 2 and the precipitate recrystallized from ethanol, to yield the 4-phenoxy-3-benzylamino-5-(2-aminophenylsulfamoyl)-benzoic acid of the formula ##SPC14##

Workup

  1. temperatureis refluxed for four hours under nitrogen
  2. filtrationis filtered
  3. customthe precipitate recrystallized from ethanol

Sources & evidence

ORD record
ord-fd829b65c5a3465b9e5f94495bbe3ac8
Source dataset
uspto-grants-1976_02
Patent number
US03939267

Reaction notes

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