反应详情

A mixture of 2-acetyl-7-bromofluorene (13.2 g.) and cuprous cyanide (8.2 g.) in quinoline (40 ml.) was heated to reflux for 40 minutes, cooled to 100° and poured into a mixture of ice-cold dilute aqueous ammonia and dichloromethane. The organic layer was separated, filtered to remove a yellow solid, washed with N-hydrochloric acid, dried over sodium sulphate and evaporated. The residual solid was recrystallised from ethanol containing a small amount of dimethylformamide to give 2-acetyl-7-cyanofluorene m.p. 182°-188°.

1. temperaturewas heated
2. temperatureto reflux for 40 minutes
3. temperaturecooled to 100°
4. customThe organic layer was separated
5. filtrationfiltered
6. customto remove a yellow solid
7. washwashed with N-hydrochloric acid
8. dry with materialdried over sodium sulphate
9. customevaporated
10. customThe residual solid was recrystallised from ethanol containing a small amount of dimethylformamide