HCID 21517657, compound → HCID 131710048, compound

Participants

Reaction Steps

1-(1-t-butoxycarbonyl-1-triphenylphosphoranylidenemethyl)-3-(triphenylmethylamino)-4-(3-p-fluorophenyl-2-oxopropylthio)azetidin-2-one (253 mg) was refluxed in dry dioxan (25 ml) under nitrogen for 24 hours. Evaporation of the solvent and chromatography of the residue on silica gave (IX) as a white solid (131 mg). νmax (CHCl3) 1775, 1715 cm-1 δ ppm (CDCl3) 1.52 (s, 3H), 3.01 (q, J = 17 Hz, 2H), 2.66- 3.12 (1H, exchange, D2O, 3.63 (q, J = 15Hz, 2H). 4.28 (d, J = 4.5Hz, 1H), 4.71 (multiplet collapsing to d, J = 4.5Hz on D2O exchange, 1H), 6.77-7.58 (m, aromatic).

Provenance & Evidence