Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-(1-Bromo-2-naphthylmethylamino)-1-phenyl-1-propanol hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Amino-1-phenylpropan-1-ol hydrochloride | HCID 9065 | — |
| 반응물 | 1-Bromonaphthalene-2-carbaldehyde | HCID 76909 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(1-Bromo-2-naphthylmethylamino)-1-phenyl-1-propanol hydrochloride | HCID 68137177 | 99% |
반응 단계
A mixture of 38.4 g (0.164 mole) 1-bromo-2-naphthaldehyde, 16.4g (0.164 mole) triethylamine, and 30.6 g (0.164 mole) of 2-amino-1-phenyl-1-propanol hydrochloride in 500 ml CH3OH was stirred and refluxed for 60 minutes, then cooled to 10°-20° while 6.23 g (0.164 mole) of sodium borohydride was added over 5 minutes. The reaction mixture was stirred at ambient temperature (15°-21°) for 60 minutes and diluted with 500 ml H2O. The mixture was stirred for 15 minutes and extracted with 2 × 350 ml CHCl3. The combined extracts were dried (MgSO4) and concentrated to dryness in vacuo to give 59.6 g (99%) of the free base.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03940400 |
| 출처 데이터셋 | uspto-grants-1976_02 |
| ORD ID | ord-f5b6f536c98b4b79a918a716e1739155 |
| 출처 메모 | uspto-grants-1976_02 |