Sodium Carbonate → HCID 86733081, compound

HRID 1578946Notes

Reaction equation

HRID 1578946 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[Cl:16][C:17]1[CH:22]=[C:21](Cl)[N:20]=[C:19]([S:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[N:18]=1>C(O)C>[Cl:16][C:17]1[CH:22]=[C:21]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=2)[N:20]=[C:19]([S:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[N:18]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 673264-FluorobenzylamineHCID 4133103Acetic acid, [(4,6-dichloro-2-pyrimidinyl)thio]-, ethyl ester

Product 1

HCID 86733081HCID 86733081, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred mixture of 3.75 g of p-fluorobenzylamine, 3.18 g of anhydrous sodium carbonate and 8.01 g of (4,6-dichloro-2-pyrimidinylthio)acetic acid, ethyl ester in 150 ml of ethanol was heated under reflux for 5 hr. The reaction mixture was filtered and water was added to the filtrate until a precipitate was formed. The solid was collected and recrystallized from benzene-petroleum ether giving 3.6 g of product, mp. 70°-75°C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. filtrationThe reaction mixture was filtered
  4. additionwater was added to the filtrate until a precipitate
  5. customwas formed
  6. customThe solid was collected
  7. customrecrystallized from benzene-petroleum ether giving 3.6 g of product, mp. 70°-75°C.

Sources & evidence

ORD record
ord-e1a473e3022a4e2fa7e46b77e4760ef6
Source dataset
uspto-grants-1976_02
Patent number
US03940394

Reaction notes

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