Sodium Carbonate → HCID 54563962, compound

HRID 1578948Notes

Reaction equation

HRID 1578948 reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][S:6][C:7]1[N:12]=[C:11](Cl)[CH:10]=[C:9]([Cl:14])[N:8]=1)[CH3:2].[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([CH2:21][CH2:22][NH2:23])=[CH:19][CH:18]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4](=[O:15])[CH2:5][S:6][C:7]1[N:8]=[C:9]([Cl:14])[CH:10]=[C:11]([NH:23][CH2:22][CH2:21][C:20]2[CH:24]=[CH:25][C:17]([Cl:16])=[CH:18][CH:19]=2)[N:12]=1)[CH3:2]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 674302-(4-Chlorophenyl)ethylamineHCID 4133103Acetic acid, [(4,6-dichloro-2-pyrimidinyl)thio]-, ethyl ester

Product 1

HCID 54563962HCID 54563962, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 10.7 g of (4,6-dichloro-2-pyrimidinylthio] acetic acid ethyl ester, 6.2 g of p-chlorophenethylamine, and 4.24 g of sodium carbonate in 150 ml. of ethanol was heated under reflux for 15 minutes. The reaction mixture was filtered and the filtrate was cooled in ice. The crystalline product which was deposited was collected and recrystallized from ethanol giving 3.6 g of product, mp. 105°-108°C.

Workup

  1. temperatureunder reflux for 15 minutes
  2. filtrationThe reaction mixture was filtered
  3. temperaturethe filtrate was cooled in ice
  4. customThe crystalline product which was deposited was collected
  5. customrecrystallized from ethanol giving 3.6 g of product, mp. 105°-108°C.

Sources & evidence

ORD record
ord-be919b9ff1ea44b2a705cd1098491e50
Source dataset
uspto-grants-1976_02
Patent number
US03940394

Reaction notes

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