反应详情

A stirred mixture of 10.0 g of (4-chloro-2-pyrimidinylthio)acetic acid, ethyl ester, 6.0 g of p-chlorobenzylamine and 4.5 g of sodium carbonate in 150 ml. of ethanol was heated under reflux for 5 hr. The reaction mixture was filtered and water was added to the filtrate to induce crystallization. After cooling in ice the precipitate was collected on a filter. Recrystallization from benzene-petroleum ether afforded 5.5 g of product, mp. 175-178°C.

1. temperatureunder reflux for 5 hr
2. filtrationThe reaction mixture was filtered
3. additionwater was added to the filtrate
4. customcrystallization
5. temperatureAfter cooling in ice the precipitate
6. customwas collected on a filter
7. customRecrystallization from benzene-petroleum ether