1-Methylpiperazine → 4-Chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine

Participants

Reaction Steps

Two grams of 4,6-dichloro-2-phenylpyrimidine is added in small portions to 10 ml. of N-methylpiperazine with slight warming and stirring. The resulting mixture is heated on a steam bath for several minutes, then poured into 250 ml. of water. The product (2.4 g., m.p. 81°-87°C.) is then recrystallized from n-pentane to afford 4-chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine, m.p. 91°-92.5°C.

Provenance & Evidence