反应详情

温度

160 °C

A well blended mixture of 3.8 g. of 4-(4-chloro-2-phenylpyrimidin-6-yl)-1-piperazineethanol and 7.0 g. of p-chlorothiophenol is heated in an oil bath maintaining the temperature at 160°C. for 3 hours. After being cooled to room temperature, the reaction mixture is triturated with 60 ml. of 30°/o sodium hydroxide. The product is collected on a sintered glass funnel and washed with water repeatedly. Upon recrystallization from 65°/o ethanol, there is obtained 4-[4-(4-chlorophenylthio)-2-phenyl-6-pyrimidinyl]-1-piperazine ethanol, m.p. 118°-120°C.

1. additionmixture of 3.8 g
2. temperatureAfter being cooled to room temperature
3. customthe reaction mixture is triturated with 60 ml
4. customof 30°
5. customThe product is collected on a sintered glass funnel
6. washwashed with water repeatedly
7. customUpon recrystallization from 65°/o ethanol