反应详情

温度

160 °C

A well blended mixture of the above prepared 4-chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine (2.0 g.) and 5.0 g. of p-chlorothiophenol is heated in an oil bath maintaining the temperature at 160°C. for 3 hours. After being cooled to room temperature, the reaction mixture is triturated with 60 ml. of 30°/o sodium hydroxide. The product is collected on a sintered glass funnel and washed with water repeatedly. It amounted to 2.9 g. and melted at 145°-150°C. Upon recrystallization from absolute ethanol, there is obtained 4-(4-chlorophenylthio)-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine, m.p. 152°-154°C.

1. additionmixture of the
2. temperatureAfter being cooled to room temperature
3. customthe reaction mixture is triturated with 60 ml
4. customof 30°
5. customThe product is collected on a sintered glass funnel
6. washwashed with water repeatedly
7. customUpon recrystallization from absolute ethanol