3-Methoxypropylamine → HCID 21557371, compound

HRID 1578982Notes

Reaction equation

HRID 1578982 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH3:16])=[CH:11][CH:10]=2)[N:3]=1.[CH3:17][O:18][CH2:19][CH2:20][CH2:21][NH2:22]>>[Cl:8][C:6]1[CH:7]=[C:2]([NH:22][CH2:21][CH2:20][CH2:19][O:18][CH3:17])[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH3:16])=[CH:11][CH:10]=2)[N:5]=1

Participants

3

Reactant 2

HCID 16723-MethoxypropylamineHCID 21557425HCID 21557425, compound

Product 1

HCID 21557371HCID 21557371, compound

Procedure

In a similar manner, 4,6-dichloro-2-(p-ethylphenyl)pyrimidine is reacted with γ-methoxypropylamine to obtain 4-chloro-2-(4-ethylphenyl)-6-[3-(methoxy)propylamino]-pyrimidine which is then reacted with thiophenol to afford 2-(4-ethylphenyl)-6-(3-methoxypropylamino)-4-phenylthiopyrimidine.

Sources & evidence

ORD record
ord-d7bed8de1c724ccb92bfaa8ca24839dd
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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