p-Chlorothiophenol → HCID 21557400, compound

Participants

Reaction Steps

A blended mixture of 6.5 g of 4-chloro-6-(2-methoxyethylamino)-2-(4-methoxyphenyl)-pyrimidine and 15.0 g. of p-chlorothiophenol is heated to 160°C. for 3 hours. Thereafter, the reaction mixture is cooled to room temperature and triturated with 60 ml. of 30°/o sodium hydroxide. The product is separated by filtration, washed with water and recrystallized from absolute ethanol to afford 6-(4-chlorophenylthio)-4-(2-methoxyethylamino)-2-(4-methoxyphenyl)pyrimidine, m.p. 117°-118.5°C.

Provenance & Evidence