p-Propoxythiophenol → 2-(4-Methoxyphenyl)-6-(4-methyl-1-piperazinyl)-4-(4-propoxyphenylthio)-pyrimidine

HRID 1578988Notes

Reaction equation

Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[N:5]=[C:4]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[N:3]=1.[CH2:23]([O:26][C:27]1[CH:32]=[CH:31][C:30]([SH:33])=[CH:29][CH:28]=1)[CH2:24][CH3:25]>>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]([C:4]2[N:3]=[C:2]([S:33][C:30]3[CH:31]=[CH:32][C:27]([O:26][CH2:23][CH2:24][CH3:25])=[CH:28][CH:29]=3)[CH:7]=[C:6]([N:8]3[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]3)[N:5]=2)=[CH:16][CH:17]=1

Participants

Reactant 2

HCID 12400145p-Propoxythiophenol

HCID 215573724-Chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine

Product 1

HCID 215574022-(4-Methoxyphenyl)-6-(4-methyl-1-piperazinyl)-4-(4-propoxyphenylthio)-pyrimidine

Procedure

In the same manner, the above prepared 4-chloro-2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-pyrimidine is reacted with p-propoxythiophenol to afford 2-(4-methoxyphenyl)-6-(4-methyl-1-piperazinyl)-4-(4-propoxyphenylthio)-pyrimidine.

Sources & evidence

ORD record: ord-3192155fe01d497699bdb2f4612f7335
Source dataset: uspto-grants-1976_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03940395

Reaction notes

Loading…