2-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione → 2-[5-[4-(2-pyridinyl)-1-piperazinyl]pentyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

HRID 1579011Notes

Reaction equation

HRID 1579011 reaction equation
[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11](CCCCN2C(=O)C3C=CC=C4C=3C(=CC=C4)C2=O)[CH2:10][CH2:9]1.Br[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][N:39]1[C:48](=[O:49])[C:47]2[CH:50]=[CH:51][CH:52]=[C:45]3[C:46]=2[C:41](=[CH:42][CH:43]=[CH:44]3)[C:40]1=[O:53].BrCCCCN1C(=O)C2C=CC=C3C=2C(=CC=C3)C1=O>>[ClH:1].[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:9][CH2:10][N:11]([CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][N:39]2[C:48](=[O:49])[C:47]3[CH:50]=[CH:51][CH:52]=[C:45]4[C:46]=3[C:41](=[CH:42][CH:43]=[CH:44]4)[C:40]2=[O:53])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 27823602-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dioneHCID 166387912-(5-Bromopentyl)benzo[de]isoquinoline-1,3-dioneHCID 1317100602-[4-[4-(2-Pyridinyl)-1-piperazinyl]butyl]-1H-benz[de]-isoquinoline-1,3-(2H)-dione, hydrochloride

Product 1

HCID 1317100612-[5-[4-(2-pyridinyl)-1-piperazinyl]pentyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

Procedure

Following the procedure of part (b) of example 46 but substituting 2-(5-bromopentyl)-1H-benz[de]isoquinoline-1,3(2H)-dione for the 2-(4-bromobutyl)-1H-benz[de]isoquinoline-1,3(2H)-dione, one obtains 2-[5-[4-(2-pyridinyl)-1-piperazinyl]pentyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride (1:2).

Sources & evidence

ORD record
ord-27cabf7762184cbdaf66482482fa8c82
Source dataset
uspto-grants-1976_02
Patent number
US03940398

Reaction notes

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