Tert-Butylamine → HCID 21557785, compound

Participants

Reaction Steps

To a solution of 1.95 g. of 4-[2(2,3-epoxypropoxy)phenyl]-1,2,3-thiadiazole in 45 ml. of t-butylamine is added 5 ml. of t-butanol, and the reaction mixture is stirred at room temperature for 5 days. It is then evaporated to dryness under vacuo. Crystallization of the residue from methylene chloride-benzene affords the pure 4-[2(3-t-butylamino-2-hydroxypropoxy)phenyl]1,2,3-thiadiazole, m.p. 99°-100° C λmax 244, 290 nm (ε 10,500, 4,600) ir 3355, 1600 cm-1.

Provenance & Evidence