4-[4-(Oxiran-2-ylmethoxy)phenyl]-1,2,3-thiadiazole → 4-[4{3-(4-Carbamoylphenoxyethylamino)2-hydroxypropoxy}phenyl]-1,2,3-thiadiazole

Participants

Reaction Steps

A mixture of 234 mg. of 4-[4(2,3-epoxypropoxy)phenyl]-1,2,3-thiadiazole, 180 mg. of 4-carbamoylphenoxyethylamine and 5 ml. of ethanol is stirred at room temperature for 68 hours. The formed precipitate is collected by filtration and recrystallized from methanol thus obtaining the pure 4-[4{3-(4-carbamoylphenoxyethylamino)2-hydroxypropoxy}phenyl]-1,2,3-thiadiazole, m.p. 173°-174° C; λmax 255 nm (ε 32,300); ir 3,345, 1605, 1570 cm-1.

Provenance & Evidence