Ethanol → HCID 21557567, compound

Participants

Reaction Steps

To a solution of 10 g. of 4-(2-hydroxyphenyl)5-carboethoxy-1,2,3-thiadiazole in 500 ml. of ethanol is added a solution of 5 g. of sodium hydroxide in 25 ml. of water. The reaction mixture is refluxed for 4 hours and then evaporated to a small volume under vacuo. It is then cooled, diluted with water and extracted with ether to eliminate unsaponifiable products. The aqueous phase is acidified with 10% hydrochloric acid solution and extracted with ethyl acetate. The combined ethyl acetate extracts are washed with sodium chloride solution, dried over sodium sulfate and evaporated to dryness under vacuo. Crystallization of the residue from ethyl acetate-methanol, affords the pure 4-(2-hydroxyphenyl)5-carboxy-1,2,3-thiadiazole.

Provenance & Evidence