Hydrochloric Acid → HCID 21557622, compound

Participants

Reaction Steps

To a solution of 80 mg. of sodium hydroxide in 10 ml. of water is added 250 mg. of 4-(4-hydroxyphenyl)-5-carboxy-1,2,3-thiadiazole. The reaction mixture is stirred for 10 minutes and then treated dropwise with 0.4 ml. of epibromohydrin, maintaining the reaction mixture at room temperature under stirring for 48 additional hours. It is then acidified with 10% hydrochloric acid solution and extracted with ethyl acetate. The combined organic extracts are dried over sodium sulfate and evaporated to dryness under reduced pressure. Crystallization of the residue from chloroformmethanol affords the pure 4-[4(2,3-epoxypropoxy)phenyl]-5-carboxy-1,2,3-thiadiazole.

Provenance & Evidence