反应详情

1,1,3,4,4,6-Hexamethyl-7-acetyl-1,2,3,4-tetrahydronaphthalene (33 gm,0.12 m) was dissolved in glacial acetic acid (40 ml.) and the solution treated portionwise with bromine (20.3 gm) with stirring. The mixture was allowed to stand overnight at room temperature and poured onto ice (100 gm.). The resulting mixture was extracted with ether (3 ×100 ml.) and the combined extracts washed with saturated sodium carbonate (2 × 50 ml.) and then brine. The washed extracts were then dried (MgSO4) and the solvent removed in vacuo to give a crystalline solid. This was recrystallised from absolute ethanol to give 1,1,3,4,4,6-hexamethyl-7-bromoacetyl-1,2,3,4-tetrahydronaphthalene as colourless needles (16 gm, 38%) m.p. 68°C. [Found: C, 64.40; H, 7.65%. C18H25BrO requires: C,64.09; H,7.47%].

1. additionpoured onto ice (100 gm.)
2. extractionThe resulting mixture was extracted with ether (3 ×100 ml.)
3. washthe combined extracts washed with saturated sodium carbonate (2 × 50 ml.)
4. dry with materialThe washed extracts were then dried (MgSO4)
5. customthe solvent removed in vacuo
6. customto give a crystalline solid
7. customThis was recrystallised from absolute ethanol