Hexylamine → HCID 131709883, compound

Participants

Reaction Conditions

Reaction Steps

50 g (0.1 mol) of Z-Pro-OH were dissolved in 400 ml of anhydrous tetrahydrofuran, 28 ml of triethyl amide were added. The mixture was cooled to -10° and then 19.5 ml (0.2 mol) of chloroformic acid ethyl ester were added dropwise. After stirring for 10 minutes at -10°C, 96 ml (1 mol) of n-hexyl amine were added portionwise at this temperature, and the whole was stirred for another 6 hours without cooling. Subsequently it was evaporated under reduced pressure and taken up with ethyl acetate. The ethyl acetate solution was extracted with a 5 % KHSO4 -solution, saturated NaHCO3 -solution and water. After evaporating the ethyl acetate solution, dried over sodium sulfate, the product was crystallized.

Provenance & Evidence