Formaldehyde → HCID 15581945, compound

HRID 1579193Notes

Reaction equation

HRID 1579193 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([NH2:10])=[S:9].[CH3:11]O.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.C=O.[CH3:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>>[O:16]1[CH2:17][CH2:18][N:13]([CH2:11][NH:10][C:8](=[S:9])[CH:7]([C:23]2[CH:22]=[CH:21][CH:26]=[CH:25][CH:24]=2)[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[CH2:14][CH2:15]1

Participants

6

Reactant 5

HCID 712FormaldehydeHCID 887MethanolHCID 8058HexaneHCID 8083MorpholineHCID 30351632-Pyridineacetamide, thio-

Product 1

HCID 15581945HCID 15581945, compound

Procedure

2-Phenyl-(2-(2-pyridyl)thioacetamide (1.14 g.) is suspended in 20 ml. of methanol. To the suspension is added 0.49 ml. of morpholine and 0.45 ml. of formalin. The mixture is heated on a steam bath until all of the materials are dissolved. The solution is then cooled and hexane is added. Concentrating to dryness and recrystallizing the residue from isopropanol gives N-morpholinomethyl-2-phenyl-2-(2-pyridyl)thioacetamide, m.p. 128°-130°C.

Workup

  1. additionTo the suspension is added 0.49 ml
  2. temperatureThe mixture is heated on a steam bath until all of the materials
  3. dissolutionare dissolved
  4. temperatureThe solution is then cooled
  5. concentrationConcentrating to dryness
  6. customrecrystallizing the residue from isopropanol

Sources & evidence

ORD record
ord-31ec43d9087041d19972824bf65a5939
Source dataset
uspto-grants-1976_01
Patent number
US03931162

Reaction notes

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