反应详情

To a pyridine solution (500 ml) of 1-aminohydantoin hydrochloride (50 g, 0.3 mole) was added cinnamoyl chloride (53 g, 0.3 mole). The stirred mixture was heated on the steam bath for 5 hours, then poured into ice water. After standing overnight, the precipitated product was removed by filtration and washed thoroughly with water. After drying, the crude white product weighed 60 g (74%). Several recrystallizations from methanol provided analytical material which melted at 276°-278°.

1. temperatureThe stirred mixture was heated on the steam bath for 5 hours
2. customthe precipitated product was removed by filtration
3. washwashed thoroughly with water
4. customAfter drying
5. customSeveral recrystallizations from methanol provided analytical material which melted at 276°-278°