反应详情

A stirred mixture of 4-chloro-3-trifluoromethylcinnamic acid (50 g, 0.2 mole) in 200 ml of SOCl2 was heated at reflux for 2 hours. The excess SOCl2 was removed in vacuo and the residue flushed with dry benzene. The residue was treated with a mixture of 1-aminohydantoin hydrochloride (30 g, 0.2 mole) in 400 ml of pyridine. The reaction mixture was heated at reflux for 3 hours; then poured into ice/HCl. The crude residue (74 g, 100%) was recrystallized from CH3NO2 (Darco) to give an analytical sample melting at 270°-273°.

1. temperaturewas heated
2. temperatureat reflux for 2 hours
3. customThe excess SOCl2 was removed in vacuo
4. customthe residue flushed with dry benzene
5. temperatureThe reaction mixture was heated
6. temperatureat reflux for 3 hours
7. customThe crude residue (74 g, 100%) was recrystallized from CH3NO2 (Darco)
8. customto give an analytical sample melting at 270°-273°