Morpholine → HCID 54493628, compound

HRID 1579214Notes

Reaction equation

HRID 1579214 reaction equation
F[B-](F)(F)F.[C:6]([N+:10]1[O:11][C:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[CH:15][C:14]=12)([CH3:9])([CH3:8])[CH3:7].[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[C:6]([N:10]1[C:14]2[CH:15]=[CH:16][C:17]([Cl:19])=[CH:18][C:13]=2[C:12]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[O:11]1)([CH3:9])([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 21568113HCID 21568113, compound

Product 1

HCID 54493628HCID 54493628, compound

Procedure

To a flask containing 6 g. of 1-tert.-butyl-5-chloro-3-phenyl-2,1-benzisoxazolium tetrafluoroborate is added 9 ml. of morpholine and the mixture heated at 80°C. with stirring for 1 hour. The reaction mixture is washed in diethyl ether and water and the ether layer separated, dried, evaporated in vacuo to dryness and the residue recrystallized from ether to obtain 1-tert.-butyl-5-chloro-3-morpholino-3-phenyl-2,1-benzisoxazoline, m.p. 130°-132°C.

Workup

  1. additionTo a flask containing 6 g
  2. washThe reaction mixture is washed in diethyl ether
  3. customwater and the ether layer separated
  4. customdried
  5. customevaporated in vacuo to dryness
  6. customthe residue recrystallized from ether

Sources & evidence

ORD record
ord-91bafccebf1747519fb62c9e6eb2685c
Source dataset
uspto-grants-1976_01
Patent number
US03931172

Reaction notes

Loading…