Dichloroacetic Acid → HCID 21568148, compound

Participants

Reaction Steps

A mixture of 27.4 g (0.120 mole) of 2,2'-methylene bis-p-cresol, 15.5 g (0.120 mole) of dichloroacetic acid, 66.5 g (0.480 mole) of potassium carbonate and 500 ml of isopropyl alcohol was refluxed for 24 hours with vigorous stirring after which 15.5 g. (0.120 mole) of dichloroacetic acid was added and the mixture was refluxed with stirring for 64 hours. The isopropyl alcohol was removed by distillation and replaced with 500 ml of water. The precipitate was collected, washed with 2% aqueous potassium hydroxide, suspended in 1 liter of water, and the suspension was acidified to litmus with 10% aqueous HCl. The resulting precipitate was collected and dried affording 2,10-dimethyl-12H-dibenzo[d,g][1,3]dioxocin-6-carboxylic acid, m.p. 200°-205°C (dec.).

Provenance & Evidence