HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanic acid → 2,5-Dimethyl-3,6-di(propan-2-yl)pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanic acid | HCID 6347 | — |
| Reactant | Methyl Isobutyl Ketone | HCID 7909 | — |
| Reactant | Nitrosyl chloride | HCID 17601 | — |
| Reactant | 4-Methyl-3-oximino-2-pentanone | HCID 6795112 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2,5-Dimethyl-3,6-di(propan-2-yl)pyrazine | HCID 13320992 | — |
Reaction Steps
d. 2,5-Dimethyl-3,6-diisopropyl-pyrazine was prepared by first forming 4-methyl-3-oximino-2-pentanone by reacting 4-methyl-2-pentanone with nitrosyl chloride according to the method of BOUVEAULT, Bull. [3] 31, 1163 (1904). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-Dimethyl-3,6-diisopropyl-pyrazine which had a b.p. of 91°C./8 mm. Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931166 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-57c1491721e841e1aed92f2ca430d4e7 |
| Source note | uspto-grants-1976_01 |