Nitric Acid → Methyl 7-Nitro-1,4-benzodioxane-6-carboxylate

Participants

Reaction Steps

To a solution of 5.0 g. of 3,4-ethylenedioxybenzoic acid methyl ester in 5.0 mls. of glacial acetic acid is added dropwise 5.0 mls. of 70% nitric acid at 50°-60°C. After addition the reaction mixture is kept at 55°C. for one hour, then cooled and 50 mls. of ice water added. The resulting precipitate is recovered by filtering, water washed and dried to obtain 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester, m.p. 115°-118°C.

Provenance & Evidence