Diethyl Sulfate → HCID 178467037, compound

Participants

Reaction Steps

14.2 g (0.1 mol) of 2-methoxy-4,6-dihydroxypyrimidine are added while stirring to 50 cc of 2N sodium hydroxide solution 2N and the mixture is stirred for half an hour with heating to 50°. 17.0 g (0.11 mol) of diethyl sulphate are subsequently added dropwise, over the course of 20 minutes and with stirring; by adding 2N sodium hydroxide solution the pH value should, if possible, be kept at between 8 and 8.2. The mixture is then stirred at 50°, 2N sodium hydroxide solution is added from time to time until the pH remains constant (after approximately 3 hours). The reaction mixture is subsequently cooled to 0°, the precipitate is suction filtered and washed with a small quantity of ethanol. After drying in a high vacuum at 80°, the substance has a M.P. of 192°-194°.

Provenance & Evidence