Hydrazine hydrate (1:1) → HCID 20360783, compound

Participants

Reaction Steps

A stirred suspension of 3-(3-hydroxy-4-methylbenzoyl) propionic acid (6.75 g, 0.032 mole) in water (40 ml) was treated with hydrazine hydrate (2.4 ml, 0.048 mole) and heated under reflux for 1 hour. The mixture was diluted with water (50 ml), cooled, and the product collected then washed with water. (6.36g, 96%, m.p. 215°-218°C). Crystallisation from ethanol gave pure 6-(3-hydroxy-4-methylphenyl)-4,5-dihydro-3(2H)-pyridazinone, m.p. 216°-218°C

Provenance & Evidence