HCID 20309579, compound → HCID 20309512, compound

Participants

Reaction Steps

A solution of 3-(2-hydroxy-5-nitrobenzoyl)propionic acid (5.5 g) in ammonium hydroxide solution (5N; 100 ml) was added to a stirred, boiling solution of ferrous sulphate heptahydrate (45 g) in water (200 ml). Stirring under reflux was continued for a further 60 minutes, ammonium hydroxide solution was added until the mixture had pH 9, the reaction mixture filtered through Kieselguhr and the filtrate evaporated to dryness. The solid residue was crystallised from ethanol to give pale yellow needles of 3-(5-amino-2-hydroxybenzoyl)propionic acid (2.2 g, 46%, m.p. 158°-160°C; M+, 209, M, 209).

Provenance & Evidence