Nitric Acid → HCID 18351994, compound

HRID 1579292Notes

Reaction equation

HRID 1579292 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.[N+:15]([O-])([OH:17])=[O:16]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 1013593-(4-Fluorobenzoyl)propionic acid

Product 1

HCID 18351994HCID 18351994, compoundYield 46%

Conditions

Temperature
-15 °C

Procedure

A suspension of 3-(4-fluorobenzoyl)propionic acid (50 g) in nitric acid (d = 1.51, 500 ml) was stirred at -15°C for 30 minutes and poured into ice/water (2 1.). The precipitate was filtered off, washed with water and recrystallised from ethanol to give 3-(4-fluoro-3-nitrobenzoyl)-propionic acid (29.2g, 46%) as needles m.p. 136°C.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-c55181184dec404dae20727a90e97f18
Source dataset
uspto-grants-1976_01
Patent number
US03931177

Reaction notes

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