Thionyl Chloride → HCID 21568326, compound

HRID 1579304Notes

Reaction equation

HRID 1579304 reaction equation
[OH:1][P:2]1(=O)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH2:3]1.S(Cl)([Cl:15])=O>>[Cl:15][P:2]1(=[O:1])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 21568315HCID 21568315, compound

Product 1

HCID 21568326HCID 21568326, compound

Procedure

1-Hydroxy-1-oxo-1,2,3,4-tetrahydrophosphinoline (2.7g, 15 mmole) was refluxed with redistilled thionyl chloride (12 ml, 170 mmole) for 2 hr, and the excess of thionyl chloride removed by distillation. Distillation of the residue (bulb to bulb) at 150°/0.005 mm gave 1-chloro-1-oxo-1,2,3,4-tetrahydrophosphinoline (34), a light yellow fuming solid (2.3g, 76%). This was used without further purification.

Workup

  1. customthe excess of thionyl chloride removed by distillation
  2. distillationDistillation of the residue (bulb to bulb) at 150°/0.005 mm

Sources & evidence

ORD record
ord-0ba3dad72bfc437da1c7dae8565abb5d
Source dataset
uspto-grants-1976_01
Patent number
US03931196

Reaction notes

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