HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Acetoxybenzoyl chloride → 4-Acetoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Acetoxybenzoyl chloride | HCID 2756254 | — |
| Reactant | 2-(2-Aminophenethyl)-1-methylpiperidine | HCID 11085282 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-Acetoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide | HCID 20560030 | — |
Reaction Steps
Reaction of 2-(o-aminophenethyl)-1-methylpiperidine with p-acetoxybenzoyl chloride in pyridine according to Example 1 provides 4-acetoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide. Analytically pure product is obtained by crystallization from isopropyl ether, m.p. 88°-108°C. (corr.). The broad melting point of the analytically pure material is due to the polymorphism.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931195 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-bdd8d70412284bb2b7b56af9eba8a264 |
| Source note | uspto-grants-1976_01 |