Acetyl chloride → HCID 13175740, compound

Participants

Reaction Steps

9.5 g of powdered aluminum chloride is added in small portions to a mixture of 5 g of 5,5-dimethyl-5H-[1]benzopyrano[2,3-b]pyridine and 5.6 g of acetyl chloride, keeping the temperature at 20°-30°C. The mixture is allowed to stand at 80°C for 1.5 hours, and then poured into ice water. The mixture is extracted with benzene, and the extract is washed with water. The benzene is distilled off, and the crystalline residue is recrystallized from isopropyl ether containing a small amount of carbon tetrachloride to give 4 g of 7-acetyl-5,5-dimethyl-5H-[1]benzopyrano[2,3-b]pyridine melting at 106°-108°C.

Provenance & Evidence