HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methylisoxazole-3-carbonyl chloride → 5-Methyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-3-isoxazolecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methylisoxazole-3-carbonyl chloride | HCID 2736894 | — |
| Reactant | 3-(2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline | HCID 49852105 | — |
| Product | 5-Methyl-N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-3-isoxazolecarboxamide | HCID 57444277 | 40% |
Reaction Steps
The title compound was prepared in 40% yield according to the general procedure for the preparation of the amides (Method B) starting from 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D6) and 5-methyl-3-isoxazolecarbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732600B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-8f69b331747347f198acfe392cdedd2e |
| Source note | uspto-grants-2010_06 |