HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → HCID 19768834, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | Benzeneacetonitrile, 4-fluoro- | HCID 68016 | — |
| Solvent | Sodium ethoxide | HCID 2723922 | — |
| Product | HCID 19768834 | HCID 19768834 | — |
Reaction Steps
By employing the procedures described in Example 1, p-fluorophenylacetonitrile is reacted with diethyl oxalate in alcoholic sodium ethoxide to give ethyl 3-cyano-3-(p-fluorophenyl)pyruvate. The latter is reacted with phenylacetonitrile and subsequent synthetic steps yield 4-fluoropulvinic acid lactone. The lactone ring is opened with 2-aminothiazole as described above to give 4-fluoro-N-(2-thiazolyl)pulvinic acid amide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931207 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-59d81703fbcb4ff1b820638a9d54e195 |
| Source note | uspto-grants-1976_01 |