HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isonicotinylacetate → Dimethyl [2-oxo-4-(pyrid-4-yl)butyl]phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isonicotinylacetate | HCID 12229233 | — |
| Reactant | Dimethyl [2-oxo-3-(pyrid-3-yloxy)propyl]phosphonate | HCID 53690992 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Dimethyl [2-oxo-4-(pyrid-4-yl)butyl]phosphonate | HCID 54171090 | — |
Reaction Steps
The process described in Example 1 for the preparation of dimethyl [2-oxo-3-(pyrid-3-yloxy)propyl]-phosphonate was repeated, using ethyl 3-(pyrid-4-yl)propionate in place of ethyl 3-pyridyloxyacetate, to give dimethyl [2-oxo-4-(pyrid-4-yl)butyl]phosphonate, RF = 0.63 (acetone). The n.m.r. spectrum in deuteriochloroform showed the following characteristic absorptions (δ values):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931206 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-5ee0898c1b0b40d68a0286d811a9eea2 |
| Source note | uspto-grants-1976_01 |