Ammonia → HCID 21568547, compound

HRID 1579500Notes

Reaction equation

HRID 1579500 reaction equation
Br[CH2:2][CH:3]([N:8]=[C:9]=[O:10])[CH2:4][CH:5]([CH3:7])[CH3:6].[NH3:11].O>COCCOC>[NH2:11][C:9]1[O:10][CH2:2][CH:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[N:8]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 21568541HCID 21568541, compound

Product 1

HCID 21568547HCID 21568547, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

21 g (0.1 mole) of 1-bromomethyl-3-methyl-butyl-isocyanate were added dropwise within 1 hour, at 8°-11° C, to a mixture of 25 ml of concentrated ammonia, 25 ml of water and 7 ml of 1,2-dimethoxyethane. Stirring was continued for 15 minutes at 12°-14° C, and then working up was carried out as described in Example 1. 11.6 g (82 percent of the theory) of oily 2-amino-4-isobutyl-2-oxazoline were obtained, which had been previously dissolved and reprecipitated from a mixture of isopropyl ether and hexane and finally evaporated in a high vacuum.

Sources & evidence

ORD record
ord-3b3f32cf0fe74c61abc2c951383423d1
Source dataset
uspto-grants-1976_01
Patent number
US03931214

Reaction notes

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