HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromopropane → Ciclazindol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | HCID 21568707 | HCID 21568707 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ciclazindol | HCID 37825 | — |
Reaction Steps
2-Amino-3-(m-chlorophenyl)-3H-indol-3-ol hydrochloride (2.3 g) is converted to its oily base then heated under reflux in ethanol (10 ml) with 1,3-dibromopropane (1.55 g) for 20 hours. On cooling the title compound is obtained as its hydrobromide, m.p. 270°-273°C (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931226 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-f528ccdb1f1f4029a1b6825c5cb3f386 |
| Source note | uspto-grants-1976_01 |