S-Methyl methanethiosulfonate → HCID 54725953, compound

Participants

Reaction Steps

A mixture of 47.0 g. (0.317 mole) of the monosodium salt of 4-hydroxy-6 -methyl-2-pyrone and 40.0 g. (0.317 mole) of methyl methanethiolsulfonate in 700 ml. of 2B absolute ethanol was heated under reflux with stirring for four hours. The solvent was then removed by evaporation in vacuo, leaving a viscous semi-solid. The crude substance was washed with water and extracted with methylene chloride. The combined extracts were dried over anhydrous sodium sulfate and evaporated in vacuo to dryness, leaving 24.8 g. of a yellow solid; which, when recrystallized from isopropanol gave 10.6 g. (20 percent) of the pure product m. 141.5°-143°C.

Provenance & Evidence