Hydrochloric Acid → HCID 54113268, compound

Participants

Reaction Steps

Sodium borohydride (1.6 g, 0.043 mole) was added in portions to a stirred mixture of 11.5 g (0.043 mole) of chloromethyl 5-(p-nitrophenyl)-2-furyl ketone in 150 ml of absolute methanol over 10 minutes at 15°-20°. The resulting solution was stirred at ambient temperature for 2.5 hours, poured into a mixture of ice and water (400 ml), and made acidic with 5% aqueous HCl. The yellow solid was collected by filtration and washed with water to give 11.5 g (100%) of title compound. Recrystallization from a MeOH--H2O mixture gave an analytical sample, m.p. 111°-113°.

Provenance & Evidence