Hydrochloric Acid → HCID 21568946, compound

Participants

Reaction Steps

To a stirred solution of 2,3-dihydro-6,7-dimethylbenzofuran-2-carboxylic acid (9 g.) and isovaleryl chloride (7.5 g.) in dichloromethane (100 ml.) at 5°C. is added aluminum chloride (20 g.) in portions over a 1 hour period. The reaction mixture is stirred at 25° for 18 hours then poured into a mixture of ice (300 g.) and hydrochloric acid (50 ml.) affording 9 lg. of 2,3-dihydro-5-isovaleryl-6,7-dimethyl-benzofuran-2-carboxylic acid which melts at 117° after recrystallization from methylcyclohexane.

Provenance & Evidence