Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Isovaleryl chloride | HCID 66054 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | HCID 12741931 | HCID 12741931 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21568949 | HCID 21568949 | — |
Reaction Steps
To a stirred solution of 6,7-dimethylbenzofuran-2-carboxylic acid (9 g.) and isovaleryl chloride (7.5 g.) in dichloromethane (100 ml.) at 5°C. is added aluminum trichloride (20 g.) in portions over a 1 hour period. The reaction mixture is stirred at 25°C. for 18 hours, poured into a mixture of ice (300 g.) and hydrochloric acid (50 ml.) to afford 5-isovaleryl-6,7-dimethylbenzofuran-2-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03931239 |
|---|
| Source dataset | uspto-grants-1976_01 |
|---|
| ORD ID | ord-41e9bf746b9446f5966fc0ded72a2cc3 |
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| Source note | uspto-grants-1976_01 |
|---|
