Hydrochloric Acid → HCID 21568956, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4,5-dimethyl-6-oxo-7-isopropyl1,2,7,8-tetrahydro-6H-indeno[5,4-b]furan-2-carboxylic acid (0.01 mole) in dimethylformamide (50 ml.) at 15°C. is treated with sodium hydride (50% dispersion in mineral oil, (0.-25 mole). The solution is warmed to 50°C., cooled to 25°C., treated with methyl iodide (0.025 mole) then warmed to 50°C. Thereafter, water (50 ml.) and 10 N sodium hydroxide (2 ml.) are added; the reaction is heated at 95°C. for 0.5 hours then poured into cold 1.0N hydrochloric acid to afford 4,5,7-trimethyl-6-oxo-7-isopropyl-1,2,7,8-tetrahydro-6H-indeno[5,4-b]furan-2-carboxylic acid.

Provenance & Evidence