HCID 12741934, compound → HCID 12741935, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4,5-dimethyl-6-oxo-7-propyl-7,8-dihydro-6H-indeno[5,4-b]furan-2-carboxylic acid (2.0 g., 0.007 mole) in aqueous sodium bicarbonate (40 ml.) is treated with 1% sodium amalgam (120 g.) and stirred at 25°C. for 18 hours. The mercury is separated and the aqueous phase is acidified with hydrochloric acid affording 2.0 g. (99%) of 4,5-dimethyl-6-hydroxy-7-propyl-1,2,7,8-tetrahydro-6H-indeno[5,4-b]furan-2-carboxylic acid which melts at 161°C. after recrystallization from nitromethane.

Provenance & Evidence