5-Nitro-4-amino-1-naphthol → 5-Nitronaphthalene-1,4-dione

Participants

Reaction Steps

5-Nitro-1,4-naphthoquinone is prepared by reducing 8-nitro-1,4-naphthoquinone-1-oxime and/or 5-nitro-1,4-naphthoquinone-1-oxime in an aqueous and/or organic reaction medium in the presence of iron (II) ions and a hydrogen halide at a temperature in the range of from -20° to 100°C, and thereafter oxidizing the 8- and and/or 5-nitro-4-amino-1-naphthol formed, or the corresponding salt, optionally without intermediate isolation, at a temperature in the range of from -10° to 100°C to form the desired 5-nitro-1,4-naphthoquinone.

Provenance & Evidence