HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanic acid → 3,6-Dipentyl-2,5-dimethylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanic acid | HCID 6347 | — |
| Reactant | 2-Octanone | HCID 8093 | — |
| Reactant | Nitrosyl chloride | HCID 17601 | — |
| Reactant | 3-Oximino-2-octanone | HCID 6798159 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3,6-Dipentyl-2,5-dimethylpyrazine | HCID 605971 | — |
Reaction Steps
g. 2,5-Dimethyl-3,6-diamyl-pyrazine was prepared by first forming 3-oximino-2-octanone by reacting 2-octanone with nitrosyl chloride according to the method of BOUVEAULT (loc.cit.). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-dimethyl-3,6-diamyl-pyrazine which had a b.p. of 78°C./0.03 mm. Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03931245 |
| Source dataset | uspto-grants-1976_01 |
| ORD ID | ord-324b977e98b144b59b699ae0ce76f11f |
| Source note | uspto-grants-1976_01 |