Chrysanthemic acid, cis-(-)- → chrysanthemic acid d-trans-form

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Reaction Steps

As in Example 1, n-butyl cis-chryanthemate (25.0 g) was treated with sodium ethoxide (2.0 g) at 150°C for 60 minutes while stirring. By gas chromatographic analysis, the product was confirmed to be a mixture of the cis-isomer and the trans-isomer in a weight ratio of 25 : 75. The product was hydrolyzed by a conventional procedure and cis-chrysanthemic acid was removed as dihydro-chrysanthemolactone to give trans-chrysanthemic acid (15.1 g).

Provenance & Evidence