Methanol → Carbamimidic acid, methyl ester, sulfate (1:1)
Reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[N:6]#[C:7][NH2:8].[CH3:9][OH:10]>>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[CH3:9][O:10][C:7](=[NH:8])[NH2:6]Participants
4
Procedure
The filtrate from the second batch of crystals was mixed with methanol, sulfuric acid, and cyanamide as described above to produce a third batch of O-methyl-isourea hydrogen sulfate, and the procedure was repeated twice more to produce a total of 6,588 g O-methyl-isourea hydrogen sulfate (93% yield). The mixed product had a melting point of 109° to 112°C and had a nitrogen content of 16.06% compared with a value of 16.27% calculated for C2H8N2O5S.
Sources & evidence
- ORD record
- ord-49af99f64cca498e8c5e214ddd430dd6
- Source dataset
- uspto-grants-1976_01
- Patent number
- US03931316
Reaction notes
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