反应详情

To a solution of 600 ml. of anhydrous ethanol and 21 g. (0.317 moles) of potassium hydroxide is added 45 ml. of thioacetic acid dropwise. To this mixture is then added 0.244 moles of α-chloro-6-methoxy-2-naphthylacetic acid and stirring is continued for 15 hours. The solid which forms is filtered off and washed with ethanol. The filtrate is evaporated to dryness and the residue is dissolved in 500 ml. of ether and washed several times with water. Drying the ether and evaporation to dryness results in α-acetylthio-6-methoxy-2-naphthylacetic acid.

1. filtrationThe solid which forms is filtered off
2. washwashed with ethanol
3. customThe filtrate is evaporated to dryness
4. dissolutionthe residue is dissolved in 500 ml
5. washof ether and washed several times with water
6. customDrying
7. customthe ether and evaporation to dryness
8. customresults in α-acetylthio-6-methoxy-2-naphthylacetic acid